The body uses starch to trigger serotonin production when there is no sunlight. Stress and depression lower serotonin levels. The low levels, in turn, increase food cravings and overeating. 2. Melatonin. Meet serotonin's offspring, melatonin. Serotonin makes melatonin from an amino acid, tryptophan. 3. Exercise. Physical exercise has been shown in several studies to be one of the best ways to boost serotonin production. Specifically, aerobic exercises such as running, biking, and even yoga are best. However, keep in mind that you need to select an activity you enjoy.